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Cellosaurus RPMI-8226/MDR10V (CVCL_J433)

[Text version]
Cell line name RPMI-8226/MDR10V
Synonyms 8226/MDR10V; 8226/MDR(10)V; DOX-10V
Accession CVCL_J433
Resource Identification Initiative To cite this cell line use: RPMI-8226/MDR10V (RRID:CVCL_J433)
Comments Population: African American.
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Selected for resistance to: ChEBI; CHEBI:9948; Verapamil (VPL).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_J431 (RPMI-8226/Dox40)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=8968098
Abbaszadegan M.R., Cress A.E., Futscher B.W., Bellamy W.T., Dalton W.S.
Evidence for cytoplasmic P-glycoprotein location associated with increased multidrug resistance and resistance to chemosensitizers.
Cancer Res. 56:5435-5442(1996)

PubMed=10095106; DOI=10.1016/S0378-1119(99)00042-6
Duan Z.-F., Feller A.J., Toh H.C., Makastorsis T., Seiden M.V.
TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line.
Gene 229:75-81(1999)

Cross-references
Cell line databases/resources cancercelllines; CVCL_J433
Encyclopedic resources Wikidata; Q54951249
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number18