| Cell line name |
RPMI-8226/Dox6 |
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| Synonyms |
RPMI 8226/DOX6; 8226/DOX6; 8226/Dox6; DOX-6; Dox6 |
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| Accession |
CVCL_J432 |
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| Resource Identification Initiative |
To cite this cell line use: RPMI-8226/Dox6 (RRID:CVCL_J432) |
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| Comments |
Population: African American.
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236. |
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| Sequence variations |
- Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
- Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
- Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0014 (RPMI-8226) |
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| Sex of cell |
Male |
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| Age at sampling |
61Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=2569359
Tong A.W., Lee J., Wang R.-M., Dalton W.S., Tsuruo T., Fay J.W., Stone M.J.
Elimination of chemoresistant multiple myeloma clonogenic colony-forming cells by combined treatment with a plasma cell-reactive monoclonal antibody and a P-glycoprotein-reactive monoclonal antibody.
Cancer Res. 49:4829-4834(1989) PubMed=10070958
Hazlehurst L.A., Foley N.E., Gleason-Guzman M.C., Hacker M.P., Cress A.E., Greenberger L.M., de Jong M.C., Dalton W.S.
Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line.
Cancer Res. 59:1021-1028(1999) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_J432
|
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| Encyclopedic resources |
Wikidata; Q54951247
|
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| Entry history |
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| Entry creation | 11-Feb-2013 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 18 |
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