| Cell line name |
SK-beta2.7 |
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| Accession |
CVCL_J125 |
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| Resource Identification Initiative |
To cite this cell line use: SK-beta2.7 (RRID:CVCL_J125) |
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| Comments |
Problematic cell line: Contaminated. Parent cell line (SKW-3) has been shown to be a KE-37 derivative.
Population: Caucasian. |
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| Sequence variations |
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg571Gln (c.1712G>A); ClinVar=VCV000819886; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly310Glu (c.929G>A); ClinVar=VCV000237678; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2197 (SKW-3) |
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| Sex of cell |
Male |
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| Age at sampling |
27Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8977199; DOI=10.4049/jimmunol.158.1.273
Weber K.S.C., York M.R., Springer T.A., Klickstein L.B.
Characterization of lymphocyte function-associated antigen 1 (LFA-1)-deficient T cell lines: the alphaL and beta2 subunits are interdependent for cell surface expression.
J. Immunol. 158:273-279(1997) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_J125
|
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| Encyclopedic resources |
Wikidata; Q54953612
|
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| Entry history |
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| Entry creation | 11-Feb-2013 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 15 |
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