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Cellosaurus HepG2 CYP3A4G/7R clone 87 (CVCL_IX10)

[Text version]
Cell line name HepG2 CYP3A4G/7R clone 87
Synonyms HepG2 C87; C87
Accession CVCL_IX10
Resource Identification Initiative To cite this cell line use: HepG2 CYP3A4G/7R clone 87 (RRID:CVCL_IX10)
Comments Population: Caucasian.
Characteristics: Transfected with a dual reporter that express RFP under the transcriptional regulation of CYP3A7 in the hepatoblast-like cell state and EGFP under the transcriptional regulation of CYP3A4.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; EGE3L; DsRed (Note=drFP583, red fluorescent protein from Discosoma sp.).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=25101946; DOI=10.1371/journal.pone.0104123; PMCID=PMC4125183
Tsuji S., Kawamura F., Kubiura M., Hayashi A., Ohbayashi T., Kazuki Y., Chesne C., Oshimura M., Tada M.
Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.
PLoS ONE 9:E104123-E104123(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IX10
Encyclopedic resources Wikidata; Q54882844
Entry history
Entry creation22-Aug-2017
Last entry update10-Sep-2024
Version number14