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Cellosaurus USPC-ARK-1 (CVCL_IV72)

[Text version]
Cell line name USPC-ARK-1
Synonyms USPC ARK-1; USPC-ARK1; USC ARK-1; ARK-1
Accession CVCL_IV72
Resource Identification Initiative To cite this cell line use: USPC-ARK-1 (RRID:CVCL_IV72)
Comments Population: African American.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
Disease Endometrial serous adenocarcinoma (NCIt: C27838)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=19920829; DOI=10.1038/sj.bjc.6605448; PMCID=PMC2813756
El-Sahwi K.S., Bellone S., Cocco E., Cargnelutti M., Casagrande F., Bellone M., Abu-Khalaf M., Buza N., Tavassoli F.A., Hui P., Silasi D.-A., Azodi M., Schwartz P.E., Rutherford T.J., Pecorelli S., Santin A.D.
In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma.
Br. J. Cancer 102:134-143(2010)

PubMed=21246534; DOI=10.1002/cncr.25891; PMCID=PMC3128671
Varughese J., Cocco E., Bellone S., de Leon M., Bellone M., Todeschini P., Schwartz P.E., Rutherford T.J., Pecorelli S., Santin A.D.
Uterine serous papillary carcinomas overexpress human trophoblast-cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal antibody.
Cancer 117:3163-3172(2011)

PubMed=23891627; DOI=10.1016/j.ajog.2013.07.020
English D.P., Bellone S., Cocco E., Bortolomai I., Pecorelli S., Lopez S., Silasi D.-A., Schwartz P.E., Rutherford T.J., Santin A.D.
Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2).
Am. J. Obstet. Gynecol. 209:465.e1-465.e9(2013)

PubMed=26325104; DOI=10.1038/bjc.2015.306; PMCID=PMC4651122
Black J.D., Lopez S., Cocco E., Bellone S., Altwerger G., Schwab C.L., English D.P., Bonazzoli E., Predolini F., Ferrari F., Ratner E., Silasi D.-A., Azodi M., Schwartz P.E., Santin A.D.
PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas.
Br. J. Cancer 113:1020-1026(2015)

PubMed=26625219; DOI=10.1038/bjc.2015.388; PMCID=PMC4705897
Black J.D., Lopez S., Cocco E., Bellone S., Altwerger G., Schwab C.L., English D.P., Bonazzoli E., Predolini F., Ferrari F., Ratner E., Silasi D.-A., Azodi M., Schwartz P.E., Santin A.D.
Erratum to: PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas.
Br. J. Cancer 113:1641-1641(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IV72
Encyclopedic resources Wikidata; Q54991940
Entry history
Entry creation03-Mar-2017
Last entry update19-Dec-2024
Version number10