ID   JHH-DIPG-1
AC   CVCL_IT47
SY   JHH-DIPG-01; JHH-DIPG1; JHH DIPG1; JHH DIPG; Johns Hopkins Hospital-Diffuse Intrinsic Pontine Glioma-1
DR   cancercelllines; CVCL_IT47
DR   Wikidata; Q54898646
RX   PubMed=25939062;
RX   PubMed=26115193;
RX   PubMed=28947132;
CC   Sequence variation: Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=25939062; PubMed=26115193).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
ST   Source(s): PubMed=25939062
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 12
ST   D16S539: 11
ST   D21S11: 30
ST   D5S818: 12,13
ST   D7S820: 11,12
ST   TH01: 6
ST   TPOX: 8,12
ST   vWA: 18,19
DI   NCIt; C94764; Diffuse intrinsic pontine glioma
DI   ORDO; Orphanet_497188; Diffuse intrinsic pontine glioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 19-12-24; Version: 14
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RX   PubMed=25939062; DOI=10.1038/nm.3855; PMCID=PMC4862411;
RA   Grasso C.S., Tang Y.-J., Truffaux N., Berlow N.E., Liu L.-N.,
RA   Debily M.-A., Quist M.J., Davis L.E., Huang E.C., Woo P.J.,
RA   Ponnuswami A., Chen S., Johung T.B., Sun W.-C., Kogiso M., Du Y.-C.,
RA   Qi L., Huang Y.-L., Hutt-Cabezas M., Warren K.E., Le Dret L.,
RA   Meltzer P.S., Mao H., Quezado M., van Vuurden D.G., Abraham J.,
RA   Fouladi M., Svalina M.N., Wang N., Hawkins C., Nazarian J.,
RA   Alonso M.M., Raabe E.H., Hulleman E., Spellman P.T., Li X.-N.,
RA   Keller C., Pal R., Grill J., Monje M.;
RT   "Functionally defined therapeutic targets in diffuse intrinsic pontine
RT   glioma.";
RL   Nat. Med. 21:555-559(2015).
//
RX   PubMed=26115193; DOI=10.1097/NEN.0000000000000216; PMCID=PMC4596247;
RA   Taylor I.C., Hutt-Cabezas M., Brandt W.D., Kambhampati M.,
RA   Nazarian J., Chang H.T., Warren K.E., Eberhart C.G., Raabe E.H.;
RT   "Disrupting NOTCH slows diffuse intrinsic pontine glioma growth,
RT   enhances radiation sensitivity, and shows combinatorial efficacy with
RT   bromodomain inhibition.";
RL   J. Neuropathol. Exp. Neurol. 74:778-790(2015).
//
RX   PubMed=28947132; DOI=10.1016/j.yexcr.2017.09.032;
RA   Meel M.H., Sewing A.C.P., Waranecki P., Metselaar D.S., Wedekind L.E.,
RA   Koster J., van Vuurden D.G., Kaspers G.J.L., Hulleman E.;
RT   "Culture methods of diffuse intrinsic pontine glioma cells determine
RT   response to targeted therapies.";
RL   Exp. Cell Res. 360:397-403(2017).
//