ID   NEM157
AC   CVCL_IT35
DR   cancercelllines; CVCL_IT35
DR   Wikidata; Q54930394
RX   PubMed=25534822;
RX   PubMed=25939062;
CC   Doubling time: 30 hours (PubMed=25534822).
CC   Sequence variation: Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=25939062).
CC   Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
ST   Source(s): PubMed=25939062
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 12
ST   D21S11: 30
ST   D5S818: 11,12
ST   D7S820: 11
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 15,16
DI   NCIt; C94764; Diffuse intrinsic pontine glioma
DI   ORDO; Orphanet_497188; Diffuse intrinsic pontine glioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   5Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 19-12-24; Version: 12
//
RX   PubMed=25534822; DOI=10.1093/neuonc/nou330; PMCID=PMC5654348;
RA   Truffaux N., Philippe C., Paulsson J., Andreiuolo F.,
RA   Guerrini-Rousseau L., Cornilleau G., Le Dret L., Richon C.,
RA   Lacroix L., Puget S., Geoerger B., Vassal G., Ostman A., Grill J.;
RT   "Preclinical evaluation of dasatinib alone and in combination with
RT   cabozantinib for the treatment of diffuse intrinsic pontine glioma.";
RL   Neuro-oncol. 17:953-964(2015).
//
RX   PubMed=25939062; DOI=10.1038/nm.3855; PMCID=PMC4862411;
RA   Grasso C.S., Tang Y.-J., Truffaux N., Berlow N.E., Liu L.-N.,
RA   Debily M.-A., Quist M.J., Davis L.E., Huang E.C., Woo P.J.,
RA   Ponnuswami A., Chen S., Johung T.B., Sun W.-C., Kogiso M., Du Y.-C.,
RA   Qi L., Huang Y.-L., Hutt-Cabezas M., Warren K.E., Le Dret L.,
RA   Meltzer P.S., Mao H., Quezado M., van Vuurden D.G., Abraham J.,
RA   Fouladi M., Svalina M.N., Wang N., Hawkins C., Nazarian J.,
RA   Alonso M.M., Raabe E.H., Hulleman E., Spellman P.T., Li X.-N.,
RA   Keller C., Pal R., Grill J., Monje M.;
RT   "Functionally defined therapeutic targets in diffuse intrinsic pontine
RT   glioma.";
RL   Nat. Med. 21:555-559(2015).
//