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Cellosaurus U-CH12 (CVCL_IR27)

[Text version]
Cell line name U-CH12
Synonyms UCH12
Accession CVCL_IR27
Resource Identification Initiative To cite this cell line use: U-CH12 (RRID:CVCL_IR27)
Comments Doubling time: 7 days (PubMed=26183925); 11-13 days (Chordoma Foundation).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
Sequence variations
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 83Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3326; PubMed=26183925

Markers:
AmelogeninX,Y
CSF1PO11,12
D1S165613,16
D2S44111
D2S133822,23
D3S135814,19
D5S81811,12
D7S8208,12
D8S117914
D10S124814,16
D12S39119,19.3
D13S31712,13
D16S53915
D18S5117,18
D19S43312,15
D21S1127,32.2
D22S104515
FGA23,24
Penta D12
Penta E12,15
TH019.3
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages https://www.chordomafoundation.org/researchers/disease-models/u-ch12/
Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A., Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A., Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A., Schultheiss M., Wirtz C.R., Moller P., Mellert K.
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-3326
Cell line databases/resources cancercelllines; CVCL_IR27
Encyclopedic resources Wikidata; Q54973614
Gene expression databases GEO; GSM1673859
GEO; GSM1673860
Entry history
Entry creation03-Mar-2017
Last entry update19-Dec-2024
Version number14