Cellosaurus cell line U-CH6 (CVCL

Cellosaurus U-CH6 (CVCL_IR26)

[Text version]

Cell line name

U-CH6

Synonyms

UCH6

Accession

CVCL_IR26

Resource Identification Initiative

To cite this cell line use: U-CH6 (RRID:CVCL_IR26)

Comments

Doubling time: 14 days (PubMed=26183925).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).

Disease

Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

56Y

Category

Cancer cell line

STR profile

Source(s): PubMed=26183925

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D1S1656	17
D2S441	11
D2S1338	18,20
D3S1358	17
D5S818	12
D7S820	10
D8S1179	12
D10S1248	17
D12S391	18
D13S317	8
D16S539	12
D18S51	15
D19S433	13,16.2
D21S11	29
D22S1045	15
FGA	19,21
Penta D	12
Penta E	13,20
TH01	8
TPOX	8,11
vWA	16

Web pages

https://www.chordomafoundation.org/researchers/disease-models/u-ch6/

Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A., Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A., Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A., Schultheiss M., Wirtz C.R., Moller P., Mellert K.
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_IR26

Encyclopedic resources

Wikidata; Q54973619

Gene expression databases

GEO; GSM1673851
GEO; GSM1673852

Entry history

Entry creation

03-Mar-2017

Last entry update

19-Dec-2024

Version number