ID   U-CH3
AC   CVCL_IR25
SY   UCH3
DR   cancercelllines; CVCL_IR25
DR   GEO; GSM1673849
DR   GEO; GSM1673850
DR   Wikidata; Q54973618
RX   PubMed=26183925;
RX   PubMed=28515451;
CC   Senescence: Seems not to grow above ~17 PDL and is therefore not going to be distributed (personal communication of Cogswell, Patty).
CC   Doubling time: 8 days (PubMed=26183925).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
ST   Source(s): PubMed=26183925
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D10S1248: 15
ST   D12S391: 17,18
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 17
ST   D19S433: 13,14
ST   D1S1656: 15,17
ST   D21S11: 30
ST   D22S1045: 11
ST   D2S1338: 18,22
ST   D2S441: 10,11
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 11,12
ST   D8S1179: 16
ST   FGA: 26
ST   Penta D: 10
ST   Penta E: 7,14
ST   TH01: 9
ST   TPOX: 8,9
ST   vWA: 17,18
DI   NCIt; C129927; Sacral chordoma
DI   ORDO; Orphanet_178; Chordoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   65Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 19-12-24; Version: 13
//
RX   PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270;
RA   von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A.,
RA   Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A.,
RA   Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.;
RT   "Preclinical characterization of novel chordoma cell systems and their
RT   targeting by pharmocological inhibitors of the CDK4/6 cell-cycle
RT   pathway.";
RL   Cancer Res. 75:3823-3831(2015).
//
RX   PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709;
RA   Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B.,
RA   von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A.,
RA   Schultheiss M., Wirtz C.R., Moller P., Mellert K.;
RT   "HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and
RT   sacral chordomas.";
RL   Sci. Rep. 7:2032-2032(2017).
//