| Cell line name |
ISH/DDP |
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| Accession |
CVCL_IR24 |
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| Resource Identification Initiative |
To cite this cell line use: ISH/DDP (RRID:CVCL_IR24) |
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| Comments |
Population: Japanese.
Doubling time: 40.1 hours (PubMed=22041447).
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Type I endometrial adenocarcinoma (NCIt: C40145) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_2529 (Ishikawa) |
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| Sex of cell |
Female |
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| Age at sampling |
39Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=22041447; DOI=10.3760/cma.j.issn.0529-567x.2011.07.012
Xu Q.-Y., Chen Y.-H., Zhao L.-J., Li X.-P., Wang J.-L., Wei L.-H.
Establishment of cisplatin-resistant human endometrial cancer cell line and the study of its resistant mechanisms.
Zhonghua Fu Chan Ke Za Zhi 46:533-537(2011) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_IR24
|
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| Encyclopedic resources |
Wikidata; Q54898277
|
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| Entry history |
|---|
| Entry creation | 03-Mar-2017 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 10 |
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