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Cellosaurus KMS-34/Cfz (CVCL_IQ85)

[Text version]
Cell line name KMS-34/Cfz
Accession CVCL_IQ85
Resource Identification Initiative To cite this cell line use: KMS-34/Cfz (RRID:CVCL_IQ85)
Comments Population: Japanese.
Characteristics: Produces IgA kappa.
Selected for resistance to: ChEBI; CHEBI:65347; Carfilzomib (Kyprolis; PX-171-007).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Trp146Ter (c.438G>A); ClinVar=VCV000428890; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2996 (KMS-34)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=26109433; DOI=10.18632/oncotarget.4530; PMCID=PMC4558117
Riz I., Hawley T.S., Hawley R.G.
KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.
Oncotarget 6:14814-14831(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IQ85
Encyclopedic resources Wikidata; Q54900183
Gene expression databases GEO; GSM1692590
GEO; GSM1692591
GEO; GSM1692592
Entry history
Entry creation03-Mar-2017
Last entry update10-Sep-2024
Version number11