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Cellosaurus KMS-11/Cfz (CVCL_IQ84)

[Text version]
Cell line name KMS-11/Cfz
Accession CVCL_IQ84
Resource Identification Initiative To cite this cell line use: KMS-11/Cfz (RRID:CVCL_IQ84)
Comments Population: Japanese.
Characteristics: Produces IgG kappa.
Selected for resistance to: ChEBI; CHEBI_65347; Carfilzomib (Kyprolis; PX-171-007).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5723; IGKJ5 + HGNC; HGNC:5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line).
  • Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2989 (KMS-11)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=26109433; DOI=10.18632/oncotarget.4530; PMCID=PMC4558117
Riz I., Hawley T.S., Hawley R.G.
KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.
Oncotarget 6:14814-14831(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IQ84
Encyclopedic resources Wikidata; Q54900166
Gene expression databases GEO; GSM1692587
GEO; GSM1692588
GEO; GSM1692589
Entry history
Entry creation03-Mar-2017
Last entry update19-Dec-2024
Version number12