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Cellosaurus PC346Flu2 (CVCL_IP23)

[Text version]
Cell line name PC346Flu2
Accession CVCL_IP23
Resource Identification Initiative To cite this cell line use: PC346Flu2 (RRID:CVCL_IP23)
Comments Characteristics: Proliferation of this cell line is androgen-independent.
Selected for resistance to: ChEBI; CHEBI:5132; Flutamide.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (PubMed=15900601).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4883 (PC-346C)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=15900601; DOI=10.1002/ijc.21201
Marques R.B., Erkens-Schulze S., de Ridder C.M.A., Hermans K.G., Waltering K., Visakorpi T., Trapman J., Romijn J.C., van Weerden W.M., Jenster G.
Androgen receptor modifications in prostate cancer cells upon long-term androgen ablation and antiandrogen treatment.
Int. J. Cancer 117:221-229(2005)

PubMed=20976069; DOI=10.1371/journal.pone.0013500; PMCID=PMC2957443
Marques R.B., Dits N.F., Erkens-Schulze S., van Weerden W.M., Jenster G.
Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models.
PLoS ONE 5:E13500-E13500(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IP23
Encyclopedic resources Wikidata; Q54938579
Gene expression databases GEO; GSM539108
GEO; GSM539109
GEO; GSM539110
GEO; GSM539111
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number12