ID   CFI-3
AC   CVCL_IN79
DR   Wikidata; Q54811444
RX   PubMed=1718974;
RX   PubMed=15463957;
CC   Population: North African.
CC   Doubling time: 24 hours (PubMed=1718974).
CC   Sequence variation: Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Ser549Asn (c.1646G>A); ClinVar=VCV000007116; Zygosity=Heterozygous (PubMed=1718974).
CC   Sequence variation: Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Asn1303Lys (c.3909C>G); ClinVar=VCV000007136; Zygosity=Heterozygous (PubMed=1718974).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pMK16).
CC   Derived from site: In situ; Fetal intestine; UBERON=UBERON_0000160.
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9640 ! CFT-1
SX   Sex unspecified
AG   18FW
CA   Transformed cell line
DT   Created: 01-12-16; Last updated: 19-12-24; Version: 12
//
RX   PubMed=1718974; DOI=10.1016/S0021-9258(18)54846-8;
RA   Chastre E., Di Gioia Y., Barbry P., Simon-Bouy B., Mornet E.,
RA   Fanen P., Champigny G., Emami S., Gespach C.;
RT   "Functional insertion of the SV40 large T oncogene in cystic fibrosis
RT   intestinal epithelium. Characterization of CFI-3 cells.";
RL   J. Biol. Chem. 266:21239-21246(1991).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//