Cellosaurus cell line JME/CF 15 (CVCL

Cellosaurus JME/CF 15 (CVCL_IN70)

Cross-references
Cell line name	JME/CF 15
Synonyms	JME/CF15
Accession	CVCL_IN70
Resource Identification Initiative	To cite this cell line use: JME/CF 15 (RRID:CVCL_IN70)
Comments	Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Nose, nasal cavity, epithelium; UBERON=UBERON_0005384.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=1701980).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=1701980; DOI=10.1152/ajplung.1990.259.6.L496 Jefferson D.M., Valentich J.D., Marini F.C., Grubman S.A., Iannuzzi M.C., Dorkin H.L., Li M., Klinger K.W., Welsh M.J. Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines. Am. J. Physiol. 259:L496-L505(1990) PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040 Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A. Established cell lines used in cystic fibrosis research. J. Cyst. Fibros. 3:191-196(2004) PubMed=19584307; DOI=10.1124/jpet.109.155341 Rafferty S., Alcolado N., Norez C., Chappe F., Pelzer S., Becq F., Chappe V. Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15. J. Pharmacol. Exp. Ther. 331:2-13(2009)
Encyclopedic resources	Wikidata; Q54899007
Entry history
Entry creation	01-Dec-2016
Last entry update	19-Dec-2024
Version number	16