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Cellosaurus WSCU01 iPS#02 (CVCL_IN40)

[Text version]
Cell line name WSCU01 iPS#02
Synonyms WSCU01 #02; WSCU01-derived iPSC clone 02
Accession CVCL_IN40
Resource Identification Initiative To cite this cell line use: WSCU01 iPS#02 (RRID:CVCL_IN40)
Comments Population: Japanese.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
  • Mutation; HGNC; HGNC:12791; WRN; Simple; p.Arg369Ter (c.1105C>T) (c.1336C>T); ClinVar=VCV000005449; Zygosity=Heterozygous (PubMed=25390333).
  • Mutation; HGNC; HGNC:12791; WRN; Simple; p.Lys1046fs*14 (c.3139-1G>C) (IVS25-1G>C); ClinVar=VCV000005447; Zygosity=Heterozygous; Note=Splice acceptor mutation (PubMed=25390333).
Disease Werner syndrome (NCIt: C3447)
Werner syndrome (ORDO: Orphanet_902)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_IN41 ! WSCU01 iPS#13
CVCL_IN42 ! WSCU01 iPS#14
Sex of cell Male
Age at sampling 63Y
Category Induced pluripotent stem cell
Publications

PubMed=25390333; DOI=10.1371/journal.pone.0112900; PMCID=PMC4229309
Shimamoto A., Kagawa H., Zensho K., Sera Y., Kazuki Y., Osaki M., Oshimura M., Ishigaki Y., Hamasaki K., Kodama Y., Yuasa S., Fukuda K., Hirashima K., Seimiya H., Koyama H., Shimizu T., Takemoto M., Yokote K., Goto M., Tahara H.
Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
PLoS ONE 9:E112900-E112900(2014)

Cross-references
Encyclopedic resources Wikidata; Q54994443
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number13