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Cellosaurus SK-MEL-28DDR1-PLXAZD (CVCL_IM75)

[Text version]
Cell line name SK-MEL-28DDR1-PLXAZD
Synonyms SkMel28DDR1-PLXAZD
Accession CVCL_IM75
Resource Identification Initiative To cite this cell line use: SK-MEL-28DDR1-PLXAZD (RRID:CVCL_IM75)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90227; Selumetinib (AZD6244).
Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=26359985; DOI=10.1016/j.cell.2015.07.061; PMCID=PMC4821508
Hugo W., Shi H.-B., Sun L., Piva M., Song C.-Y., Kong X.-J., Moriceau G., Hong A., Dahlman K.B., Johnson D.B., Sosman J.A., Ribas A., Lo R.S.
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance.
Cell 162:1271-1285(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IM75
Encyclopedic resources Wikidata; Q54954028
Gene expression databases GEO; GSM1588921
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number16