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Cellosaurus M238R1-PLX (CVCL_IM74)

[Text version]
Cell line name M238R1-PLX
Accession CVCL_IM74
Resource Identification Initiative To cite this cell line use: M238R1-PLX (RRID:CVCL_IM74)
Comments Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D751 (M238)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26359985; DOI=10.1016/j.cell.2015.07.061; PMCID=PMC4821508
Hugo W., Shi H.-B., Sun L., Piva M., Song C.-Y., Kong X.-J., Moriceau G., Hong A., Dahlman K.B., Johnson D.B., Sosman J.A., Ribas A., Lo R.S.
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance.
Cell 162:1271-1285(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IM74
Encyclopedic resources Wikidata; Q54903557
Gene expression databases GEO; GSM1588918
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number11