ID   A2780/Taxol
AC   CVCL_IJ13
SY   A2780/T
DR   cancercelllines; CVCL_IJ13
DR   ChEMBL-Cells; CHEMBL4483130
DR   ChEMBL-Targets; CHEMBL4483224
DR   Wikidata; Q54606608
RX   PubMed=24175763;
CC   Population: African American.
CC   Doubling time: 24.22 +- 0.22 hours (PubMed=24175763).
CC   Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
CC   Sequence variation: Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0134 ! A2780
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 12
//
RX   PubMed=24175763; DOI=10.7314/APJCP.2013.14.9.4983;
RA   Wang N.-N., Zhao L.-J., Wu L.-N., He M.-F., Qu J.-W., Zhao Y.-B.,
RA   Zhao W.-Z., Li J.-S., Wang J.-H.;
RT   "Mechanistic analysis of taxol-induced multidrug resistance in an
RT   ovarian cancer cell line.";
RL   Asian Pac. J. Cancer Prev. 14:4983-4988(2013).
//