ID   HL-60/S4
AC   CVCL_II77
DR   ATCC; CRL-3306
DR   cancercelllines; CVCL_II77
DR   Wikidata; Q54889808
RX   PubMed=1737356;
RX   PubMed=31988093;
CC   Population: Caucasian.
CC   Characteristics: Differentiation to a granulocyte-like state can be induced by retinoic acid (RA).
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Omics: DNA methylation analysis.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC=CRL-3306
ST   Amelogenin: X
ST   CSF1PO: 13,14
ST   D13S317: 8,11
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 11,12
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 02-05-24; Version: 17
//
RX   PubMed=1737356;
RA   Leung M.-F., Sokoloski J.A., Sartorelli A.C.;
RT   "Changes in microtubules, microtubule-associated proteins, and
RT   intermediate filaments during the differentiation of HL-60 leukemia
RT   cells.";
RL   Cancer Res. 52:949-954(1992).
//
RX   PubMed=31988093; DOI=10.1242/bio.044222;
RA   Antwi E.B., Olins A., Teif V.B., Bieg M., Bauer T., Gu Z.-G., Brors B.,
RA   Eils R., Olins D., Ishaque N.;
RT   "Whole-genome fingerprint of the DNA methylome during chemically
RT   induced differentiation of the human AML cell line HL-60/S4.";
RL   Biol. Open 9:bio044222.1-bio044222.11(2020).
//