ID   HMC3
AC   CVCL_II76
SY   Human Microglia Clone 3; CHME-3; CHME3
DR   ATCC; CRL-3304
DR   CLS; 300102
DR   Ubigene; YC-C131
DR   Wikidata; Q54889911
RX   PubMed=7478261;
RX   PubMed=16371321;
RX   PubMed=20375612;
RX   PubMed=30200996;
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Fetal brain; UBERON=UBERON_0006238.
CC   Cell type: Microglial cell; CL=CL_0000129.
ST   Source(s): ATCC=CRL-3304; CLS=300102
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D12S391: 16,21
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 18
ST   D19S433: 15,15.2
ST   D21S11: 30,31.2
ST   D2S1338: 17,25
ST   D3S1358: 16,18
ST   D5S818: 11,12
ST   D6S1043: 11
ST   D7S820: 9,11
ST   D8S1179: 13,14
ST   FGA: 21,25
ST   Penta D: 10,14
ST   Penta E: 7,13
ST   TH01: 6
ST   TPOX: 8,9
ST   vWA: 17,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   8-10FW
CA   Transformed cell line
DT   Created: 01-12-16; Last updated: 10-09-24; Version: 12
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RX   PubMed=7478261; DOI=10.1016/0304-3940(94)11792-H;
RA   Janabi N., Peudenier S., Heron B., Ng K.H., Tardieu M.;
RT   "Establishment of human microglial cell lines after transfection of
RT   primary cultures of embryonic microglial cells with the SV40 large T
RT   antigen.";
RL   Neurosci. Lett. 195:105-108(1995).
//
RX   PubMed=16371321; DOI=10.1007/BF03033980;
RA   Lindberg C., Hjorth E., Post C., Winblad B., Schultzberg M.;
RT   "Cytokine production by a human microglial cell line: effects of
RT   beta-amyloid and alpha-melanocyte-stimulating hormone.";
RL   Neurotox. Res. 8:267-276(2005).
//
RX   PubMed=20375612; DOI=10.1159/000235563;
RA   Li B., Bedard K., Sorce S., Hinz B., Dubois-Dauphin M., Krause K.-H.;
RT   "NOX4 expression in human microglia leads to constitutive generation
RT   of reactive oxygen species and to constitutive IL-6 expression.";
RL   J. Innate Immun. 1:570-581(2009).
//
RX   PubMed=30200996; DOI=10.1186/s12974-018-1288-0; PMCID=PMC6131758;
RA   Dello Russo C., Cappoli N., Coletta I., Mezzogori D., Paciello F.,
RA   Pozzoli G., Navarra P., Battaglia A.;
RT   "The human microglial HMC3 cell line: where do we stand? A systematic
RT   literature review.";
RL   J. Neuroinflammation 15:259.1-259.24(2018).
//