| Cell line name |
CEM-R6 |
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| Accession |
CVCL_HF38 |
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| Resource Identification Initiative |
To cite this cell line use: CEM-R6 (RRID:CVCL_HF38) |
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| Comments |
Population: Caucasian.
Characteristics: Glucocorticoids resistant.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7978; NR3C1; Simple; p.Leu753Phe (c.2259A>T); ClinVar=VCV000016149; Zygosity=Heterozygous (PubMed=7812967).
- Mutation; HGNC; 7978; NR3C1; Unexplicit; A>G mutation in the 3'-splice junction of intron G; Zygosity=Heterozygous (PubMed=7812967).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0207 (CCRF-CEM) |
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| Sex of cell |
Female |
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| Age at sampling |
3Y11M |
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| Category |
Cancer cell line |
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| Publications | PubMed=7812967
Strasser-Wozak E.M.C., Hattmannstorfer R., Hala M., Hartmann B.L., Fiegl M., Geley S., Kofler R.
Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line.
Cancer Res. 55:348-353(1995) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_HF38
|
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| Encyclopedic resources |
Wikidata; Q54809253
|
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| Entry history |
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| Entry creation | 01-Dec-2016 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 17 |
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