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Cellosaurus SW48 TP53(+/-) (CVCL_HE26)

[Text version]
Cell line name SW48 TP53(+/-)
Synonyms TP53 (+/-) SW48
Accession CVCL_HE26
Resource Identification Initiative To cite this cell line use: SW48 TP53(+/-) (RRID:CVCL_HE26)
Comments Population: Caucasian.
Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 11998; TP53 (Note=1 of 2 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Arg2714Cys (c.8140C>T); ClinVar=VCV000231255; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Ser14fs*29 (c.41_44delCTCT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Glu67fs (c.200delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Tyr (c.98C>A); ClinVar=VCV000017577; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1724 (SW48)
Sex of cell Female
Age at sampling 83Y
Category Cancer cell line
Publications

PubMed=19225112; DOI=10.1073/pnas.0813333106; PMCID=PMC2656188
Sur S., Pagliarini R., Bunz F., Rago C., Diaz L.A. Jr., Kinzler K.W., Vogelstein B., Papadopoulos N.
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.
Proc. Natl. Acad. Sci. U.S.A. 106:3964-3969(2009)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+R06-001
Cell line databases/resources cancercelllines; CVCL_HE26
Encyclopedic resources Wikidata; Q54971153
Entry history
Entry creation01-Dec-2016
Last entry update30-Jan-2024
Version number13