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Cellosaurus RKO FANCG(+/-) (CVCL_HE21)

[Text version]
Cell line name RKO FANCG(+/-)
Synonyms FANCG (+/-) RKO
Accession CVCL_HE21
Resource Identification Initiative To cite this cell line use: RKO FANCG(+/-) (RRID:CVCL_HE21)
Comments Knockout cell: Method=Homologous recombination; HGNC; HGNC:3588; FANCG (Note=1 of 2 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16762635; DOI=10.1053/j.gastro.2006.03.016
Gallmeier E., Calhoun E.S., Rago C., Brody J.R., Cunningham S.C., Hucl T., Gorospe M., Kohli M., Lengauer C., Kern S.E.
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 130:2145-2154(2006)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+R05-002
Cell line databases/resources cancercelllines; CVCL_HE21
Encyclopedic resources Wikidata; Q54950551
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number12