Cellosaurus cell line RKO FANCC(+/-/-) (CVCL

Cellosaurus RKO FANCC(+/-/-) (CVCL_HE19)

Cross-references
Cell line name	RKO FANCC(+/-/-)
Synonyms	FANCC (+/-/-) RKO
Accession	CVCL_HE19
Resource Identification Initiative	To cite this cell line use: RKO FANCC(+/-/-) (RRID:CVCL_HE19)
Comments	Characteristics: RKO carries a stable triplication of the FANCC gene. Knockout cell: Method=Homologous recombination; HGNC; HGNC:3584; FANCC (Note=1 of 3 alleles). Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations	Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease	Colon carcinoma (NCIt: C4910)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0504 (RKO)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=16762635; DOI=10.1053/j.gastro.2006.03.016 Gallmeier E., Calhoun E.S., Rago C., Brody J.R., Cunningham S.C., Hucl T., Gorospe M., Kohli M., Lengauer C., Kern S.E. Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options. Gastroenterology 130:2145-2154(2006)
Cell line collections (Providers)	Horizon_Discovery; HD+R05-004
Cell line databases/resources	cancercelllines; CVCL_HE19
Encyclopedic resources	Wikidata; Q54950549
Entry history
Entry creation	01-Dec-2016
Last entry update	19-Dec-2024
Version number	13