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Cellosaurus NALM-6 TOP1(+/-) (CVCL_HE09)

[Text version]
Cell line name NALM-6 TOP1(+/-)
Synonyms TOP1 (+/-) NALM-6; TOP1 +/- Nalm-6
Accession CVCL_HE09
Resource Identification Initiative To cite this cell line use: NALM-6 TOP1(+/-) (RRID:CVCL_HE09)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:11986; TOP1 (Note=1 of 2 alleles).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=19336913; DOI=10.1248/bpb.32.724
Toyoda E., Kurosawa A., Fujii M., Adachi N.
Heterozygous disruption of the DNA topoisomerase I gene confers cellular resistance to camptothecin in human cells.
Biol. Pharm. Bull. 32:724-727(2009)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+115-072
Cell line databases/resources cancercelllines; CVCL_HE09
Encyclopedic resources Wikidata; Q54907432
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number15