ID   NALM-6 PRKDC(+/-)
AC   CVCL_HE07
SY   PRKDC (+/-) NALM-6
DR   cancercelllines; CVCL_HE07
DR   Horizon_Discovery; HD+R08-001
DR   Wikidata; Q54907430
RX   PubMed=18710952;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 9413; PRKDC (Note=1 of 2 alleles).
CC   Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0092 ! NALM-6
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 30-01-24; Version: 14
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RX   PubMed=18710952; DOI=10.1128/mcb.00355-08;
RA   Ruis B.L., Fattah K.R., Hendrickson E.A.;
RT   "The catalytic subunit of DNA-dependent protein kinase regulates
RT   proliferation, telomere length, and genomic stability in human somatic
RT   cells.";
RL   Mol. Cell. Biol. 28:6182-6195(2008).
//