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Cellosaurus KMS-11 WHSC1(trans/-) (CVCL_HE03)

[Text version]
Cell line name KMS-11 WHSC1(trans/-)
Synonyms WHSC1 (trans/-) KMS-11; KMS-11 MMSET Non-T-KO; KMS-11/NTKO; KMS11/NTKO; NTKO
Accession CVCL_HE03
Resource Identification Initiative To cite this cell line use: KMS-11 WHSC1(trans/-) (RRID:CVCL_HE03)
Comments Population: Japanese.
Characteristics: Produces IgG kappa.
Characteristics: In KMS-11 one of the two WHSC1 alleles is translocated. This cell line is KO for the non-translocated allele.
Knockout cell: Method=Homologous recombination; HGNC; 12766; NSD2 (Note=1 of 2 alleles).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line).
  • Mutation; HGNC; 3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2989 (KMS-11)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=17942756; DOI=10.1182/blood-2007-05-088674; PMCID=PMC2200833
Lauring J., Abukhdeir A.M., Konishi H., Garay J.P., Gustin J.P., Wang Q., Arceci R.J., Matsui W., Park B.H.
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.
Blood 111:856-864(2008)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+108-001
Cell line databases/resources cancercelllines; CVCL_HE03
Anatomy/cell type resources BTO; BTO:0005875
Encyclopedic resources Wikidata; Q54900164
Entry history
Entry creation01-Dec-2016
Last entry update10-Sep-2024
Version number15