Cellosaurus cell line KMS-11 WHSC1(+/-) (CVCL

Cellosaurus KMS-11 WHSC1(+/-) (CVCL_HE02)

Cross-references
Cell line name	KMS-11 WHSC1(+/-)
Synonyms	WHSC1 (+/-) KMS-11; KMS-11 MMSET T-KO; KMS-11/TKO; KMS11/TKO; TKO
Accession	CVCL_HE02
Resource Identification Initiative	To cite this cell line use: KMS-11 WHSC1(+/-) (RRID:CVCL_HE02)
Comments	Population: Japanese. Characteristics: Produces IgG kappa. Characteristics: In KMS-11 one of the two WHSC1 alleles is translocated. This cell line is KO for the translocated allele. Knockout cell: Method=Homologous recombination; HGNC; 12766; NSD2 (Note=1 of 2 alleles). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. Cell type: B-cell; CL=CL_0000236.
Sequence variations	Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line). Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line). Mutation; HGNC; 3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line). Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
Disease	Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_2989 (KMS-11)
Sex of cell	Female
Age at sampling	67Y
Category	Cancer cell line
Publications	PubMed=17942756; DOI=10.1182/blood-2007-05-088674; PMCID=PMC2200833 Lauring J., Abukhdeir A.M., Konishi H., Garay J.P., Gustin J.P., Wang Q., Arceci R.J., Matsui W., Park B.H. The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood 111:856-864(2008)
Cell line collections (Providers)	Horizon_Discovery; HD+108-002
Cell line databases/resources	cancercelllines; CVCL_HE02
Anatomy/cell type resources	BTO; BTO:0005876
Encyclopedic resources	Wikidata; Q54900163
Entry history
Entry creation	01-Dec-2016
Last entry update	10-Sep-2024
Version number	15