ID   HCT 116 KRAS(+/-)
AC   CVCL_HD81
SY   KRAS (+/-) HCT116
DR   cancercelllines; CVCL_HD81
DR   Horizon_Discovery; HD+104-008
DR   Wikidata; Q54881959
RX   PubMed=19661383;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 6407; KRAS (Note=1 of 2 alleles).
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 30-01-24; Version: 13
//
RX   PubMed=19661383; DOI=10.1126/science.1174229;
RA   Yun J., Rago C., Cheong I., Pagliarini R., Angenendt P.,
RA   Rajagopalan H., Schmidt K., Willson J.K.V., Markowitz S.D., Zhou S.-B.,
RA   Diaz L.A. Jr., Velculescu V.E., Lengauer C., Kinzler K.W.,
RA   Vogelstein B., Papadopoulos N.;
RT   "Glucose deprivation contributes to the development of KRAS pathway
RT   mutations in tumor cells.";
RL   Science 325:1555-1559(2009).
//