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Cellosaurus DLD-1 AKT1(-/-) (CVCL_HD52)

[Text version]
Cell line name DLD-1 AKT1(-/-)
Synonyms AKT1 (-/-) DLD-1
Accession CVCL_HD52
Resource Identification Initiative To cite this cell line use: DLD-1 AKT1(-/-) (RRID:CVCL_HD52)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:391; AKT1.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0248 (DLD-1)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=20133737; DOI=10.1073/pnas.0914018107; PMCID=PMC2823889
Ericson K., Gan C., Cheong I., Rago C., Samuels Y., Velculescu V.E., Kinzler K.W., Huso D.L., Vogelstein B., Papadopoulos N.
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Proc. Natl. Acad. Sci. U.S.A. 107:2598-2603(2010)

PubMed=27878243; DOI=10.3892/ijo.2016.3771; PMCID=PMC5182003
Haggblad Sahlberg S., Mortensen A.C., Haglof J., Engskog M.K.R., Arvidsson T., Pettersson C., Glimelius B., Stenerlow B., Nestor M.
Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.
Int. J. Oncol. 50:5-14(2017)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+R00-001
Encyclopedic resources Wikidata; Q54831149
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number7