ID   ZP139
AC   CVCL_HB19
DR   Wikidata; Q54996025
RX   PubMed=9418886;
RX   PubMed=11330042;
RX   PubMed=17045664;
RX   PubMed=23009329;
CC   Characteristics: Selected using the 9-(1'-pyrene)nonanol/ultraviolet (P9OH/UV) method. P9OH acts as a photosensitizer. Normal cells which can incorporate the fluorescent fatty alcohol into lipids are killed by UV, but mutants who incorporate P9OH poorly are less susceptible to photosensitized killing.
CC   Sequence variation: Mutation; UniProtKB; Q920N5; Pex5; Simple; p.Gly530Glu (c.1589G>A) (G480E); Zygosity=Homozygous (PubMed=9418886).
CC   Genetic integration: Method=Transfection/transduction; Gene=RGD; 61814; Pex2.
CC   Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_HB34 ! CHOTKa
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 01-12-16; Last updated: 10-09-24; Version: 13
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RX   PubMed=9418886; DOI=10.1128/mcb.18.1.388; PMCID=PMC121509;
RA   Otera H., Okumoto K., Tateishi K., Ikoma Y., Matsuda E., Nishimura M.,
RA   Tsukamoto T., Osumi T., Ohashi K., Higuchi O., Fujiki Y.;
RT   "Peroxisome targeting signal type 1 (PTS1) receptor is involved in
RT   import of both PTS1 and PTS2: studies with PEX5-defective CHO cell
RT   mutants.";
RL   Mol. Cell. Biol. 18:388-399(1998).
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RX   PubMed=11330042; DOI=10.1385/CBB:32:1-3:155;
RA   Fujiki Y., Okumoto K., Otera H., Tamura S.;
RT   "Peroxisome biogenesis and molecular defects in peroxisome assembly
RT   disorders.";
RL   Cell Biochem. Biophys. 32:155-164(2000).
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RX   PubMed=17045664; DOI=10.1016/j.bbamcr.2006.09.012;
RA   Fujiki Y., Okumoto K., Kinoshita N., Ghaedi K.;
RT   "Lessons from peroxisome-deficient Chinese hamster ovary (CHO) cell
RT   mutants.";
RL   Biochim. Biophys. Acta 1763:1374-1381(2006).
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RX   PubMed=23009329; DOI=10.1042/bj20120911;
RA   Natsuyama R., Okumoto K., Fujiki Y.;
RT   "Pex5p stabilizes Pex14p: a study using a newly isolated pex5 CHO cell
RT   mutant, ZPEG101.";
RL   Biochem. J. 449:195-207(2013).
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