ID   Melligen
AC   CVCL_HA63
DR   cancercelllines; CVCL_HA63
DR   Wikidata; Q54905184
RX   Patent=US10738285;
RX   PubMed=26029722;
WW   http://www.diabetes.co.uk/forum/threads/potential-type-1-diabetes-treatment-receives-us-patent-approval.102547/
CC   Group: Patented cell line.
CC   Population: Japanese.
CC   Characteristics: Produces insulin in response to extracellular glucose levels that are equivalent to physiological glucose levels.
CC   Characteristics: When transplanted into diabetic immunoincompetent mice, Melligen cells restore normoglycemia.
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 4195; GCK.
CC   Transfected with: HGNC; 6081; INS.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_HA62 ! HUH7-ins
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 14
//
RX   Patent=US10738285;
RA   Simpson A.M., Tao C.;
RT   "Cells genetically modified to comprise pancreatic islet glucokinase
RT   and uses thereof.";
RL   Patent number US10738285, 11-Aug-2020.
//
RX   PubMed=26029722; DOI=10.1038/mtm.2015.11;
RA   Lawandi J., Tao C., Ren B.-H., Williams P., Ling D., Swan M.A.,
RA   Nassif N.T., Torpy F.R., O'Brien B.A., Simpson A.M.;
RT   "Reversal of diabetes following transplantation of an
RT   insulin-secreting human liver cell line: Melligen cells.";
RL   Mol. Ther. Methods Clin. Dev. 2:15011-15011(2015).
//