ID   HEP G2ins/g
AC   CVCL_HA61
SY   HEPG2ins/g; HepG2ins/g
DR   cancercelllines; CVCL_HA61
DR   Wikidata; Q54882749
RX   Patent=WO1995032740A1;
RX   PubMed=9425444;
RX   PubMed=12958175;
CC   Group: Patented cell line.
CC   Population: Caucasian.
CC   Characteristics: Synthesizes, stores and secretes insulin in a regulated manner when exposed to glucose in tissue culture.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 6081; INS.
CC   Transfected with: HGNC; 11006; SLC2A2.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_HA60 ! HEP G2ins
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 17
//
RX   Patent=WO1995032740A1;
RA   Tuch B.E., Simpson A.M., Marshall G.M.;
RT   "Transformed human hepatoma cell line which releases insulin.";
RL   Patent number WO1995032740A1, 07-Dec-1995.
//
RX   PubMed=9425444; DOI=10.1038/sj.gt.3300527;
RA   Simpson A.M., Marshall G.M., Tuch B.E., Maxwell L., Szymanska B.,
RA   Tu J., Beynon S., Swan M.A., Camacho M.;
RT   "Gene therapy of diabetes: glucose-stimulated insulin secretion in a
RT   human hepatoma cell line (HEP G2ins/g).";
RL   Gene Ther. 4:1202-1215(1997).
//
RX   PubMed=12958175; DOI=10.1096/fj.02-0051fje;
RA   Liu G.-J., Simpson A.M., Swan M.A., Tao C., Tuch B.E., Crawford R.M.,
RA   Jovanovic A., Martin D.K.;
RT   "ATP-sensitive potassium channels induced in liver cells after
RT   transfection with insulin cDNA and the GLUT 2 transporter regulate
RT   glucose-stimulated insulin secretion.";
RL   FASEB J. 17:1682-1684(2003).
//