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Cellosaurus FE-PD (CVCL_H614)

[Text version]
Cell line name FE-PD
Synonyms FEPD; FePD
Accession CVCL_H614
Resource Identification Initiative To cite this cell line use: FE-PD (RRID:CVCL_H614)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 56 hours (PubMed=8035614).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Donor information: Originally the patient was suffering from Hodgkin lymphoma.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 6190; JAK1; Simple; p.Gly1097Val (c.3290_3291delinsTT); Zygosity=Unspecified (PubMed=28356514).
  • Mutation; HGNC; 11364; STAT3; Simple; p.Gly618Arg (c.1852G>C); ClinVar=VCV001192236; Zygosity=Unspecified (PubMed=28356514).
Disease Anaplastic large cell lymphoma, ALK-negative (NCIt: C37194)
ALK-negative anaplastic large cell lymphoma (ORDO: Orphanet_300903)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=8035614
Del Mistro A., Leszl A., Bertorelle R., Calabro M.L., Panozzo M., Menin C., D'Andrea E., Chieco-Bianchi L.
A CD30-positive T cell line established from an aggressive anaplastic large cell lymphoma, originally diagnosed as Hodgkin's disease.
Leukemia 8:1214-1219(1994)

PubMed=8558920
Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15356658; DOI=10.1038/sj.leu.2403465
Drexler H.G., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.
Leukemia 18:1569-1571(2004)

PubMed=16596703; DOI=10.1002/pmic.200500647
Cussac D., Pichereaux C., Colomba A., Capilla F., Pont F., Gaits-Iacovoni F., Lamant L., Espinos E., Burlet-Schiltz O., Monsarrat B., Delsol G., Payrastre B.
Proteomic analysis of anaplastic lymphoma cell lines: identification of potential tumour markers.
Proteomics 6:3210-3222(2006)

PubMed=26657151; DOI=10.1038/onc.2015.456; PMCID=PMC4907875
Ceccon M., Merlo M.E.B., Mologni L., Poggio T., Varesio L.M., Menotti M., Bombelli S., Rigolio R., Manazza A.D., Di Giacomo F., Ambrogio C., Giudici G., Casati C., Mastini C., Compagno M., Turner S.D., Gambacorti-Passerini C., Chiarle R., Voena C.
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.
Oncogene 35:3854-3865(2016)

PubMed=28356514; DOI=10.1073/pnas.1700682114; PMCID=PMC5393253
Chen J., Zhang Y., Petrus M.N., Xiao W.-M., Nicolae A., Raffeld M., Pittaluga S., Bamford R.N., Nakagawa M., Ouyang S.T.-Y., Epstein A.L., Kadin M.E., Del Mistro A., Woessner R.D., Jaffe E.S., Waldmann T.A.
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Proc. Natl. Acad. Sci. U.S.A. 114:3975-3980(2017)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_H614
Cell_Model_Passport; SIDM01496
DepMap; ACH-001068
Anatomy/cell type resources BTO; BTO:0005005
Chemistry resources ChEMBL-Cells; CHEMBL3307722
ChEMBL-Targets; CHEMBL614866
PubChem_Cell_line; CVCL_H614
Encyclopedic resources Wikidata; Q54834716
Gene expression databases GEO; GSM1217152
GEO; GSM2527948
Polymorphism and mutation databases Cosmic; 1086362
Cosmic; 2013354
Cosmic; 2024370
Cosmic; 2402467
Cosmic; 2674500
Cosmic; 2814459
Progenetix; CVCL_H614
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number21