ID   BE [Human colon carcinoma]
AC   CVCL_H580
DR   cancercelllines; CVCL_H580
DR   ChEMBL-Cells; CHEMBL3307709
DR   ChEMBL-Targets; CHEMBL614798
DR   Cosmic; 724835
DR   GEO; GSM1374398
DR   GEO; GSM1374399
DR   PubChem_Cell_line; CVCL_H580
DR   Wikidata; Q54795836
RX   PubMed=626984;
RX   PubMed=1737339;
RX   PubMed=6256643;
RX   PubMed=9865924;
RX   PubMed=12068308;
RX   PubMed=22282976;
CC   Part of: KuDOS 95 cell line panel.
CC   From: Giovanella B.C.; St. Joseph's Hospital Cancer Research Laboratory; Houston; USA.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Unspecified (PubMed=12068308).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (PubMed=12068308).
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 14
//
RX   PubMed=626984;
RA   Erickson L.C., Osieka R., Kohn K.W.;
RT   "Differential repair of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-
RT   nitrosourea-induced DNA damage in two human colon tumor cell lines.";
RL   Cancer Res. 38:802-808(1978).
//
RX   PubMed=1737339;
RA   Traver R.D., Horikoshi T., Danenberg K.D., Stadlbauer T.H.W.,
RA   Danenberg P.V., Ross D., Gibson N.W.;
RT   "NAD(P)H:quinone oxidoreductase gene expression in human colon
RT   carcinoma cells: characterization of a mutation which modulates
RT   DT-diaphorase activity and mitomycin sensitivity.";
RL   Cancer Res. 52:797-802(1992).
//
RX   PubMed=6256643; DOI=10.1038/288724a0;
RA   Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A.,
RA   Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.;
RT   "Defective repair of alkylated DNA by human tumour and
RT   SV40-transformed human cell strains.";
RL   Nature 288:724-727(1980).
//
RX   PubMed=9865924;
RA   Winski S.L., Hargreaves R.H.J., Butler J., Ross D.;
RT   "A new screening system for NAD(P)H:quinone oxidoreductase
RT   (NQO1)-directed antitumor quinones: identification of a new
RT   aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.";
RL   Clin. Cancer Res. 4:3083-3088(1998).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=22282976; DOI=10.1093/carcin/1.1.21;
RA   Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A.,
RA   Mattern M.R.;
RT   "Human tumor cell strains defective in the repair of alkylation
RT   damage.";
RL   Carcinogenesis 1:21-32(1980).
//