ID   ST-4
AC   CVCL_H267
DR   Cosmic; 1086321
DR   Wikidata; Q54955733
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3257718;
RX   PubMed=8558920;
CC   Problematic cell line: Contaminated. Shown to be a PF-382 derivative. Originally thought to originate from the axillary lymph node biopsy of a 12 year old boy with a T-cell malignant lymphoma.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2493fs*67 (c.7476_7477ins11); Zygosity=Heterozygous (from parent cell line).
CC   Derived from sampling site: Pleural effusion. Cell type=T-cell.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1641 ! PF-382
SX   Female
AG   6Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 21-03-23; Version: 16
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
RX   PubMed=3257718;
RA   Arione R., Jemma C., Forni M., Marchese C., Benetton G.,
RA   Giubellino C., Modesti A., Martinotti M.G., di Montezemolo L.C.,
RA   Musso T., Forni G.;
RT   "A new childhood T-cell lymphoma established in nude mice and in
RT   vitro.";
RL   Cancer Res. 48:1312-1318(1988).
RX   PubMed=8558920;
RA   Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M.,
RA   Quentmeier H., Drexler H.G.;
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).