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Cellosaurus U266/ADM (CVCL_GZ72)

[Text version]
Cell line name U266/ADM
Accession CVCL_GZ72
Resource Identification Initiative To cite this cell line use: U266/ADM (RRID:CVCL_GZ72)
Comments Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=26045737; PMCID=PMC4440046
Xu P., Jiang Y.-F., Wang J.-H.
shRNA-mediated silencing of sorcin increases drug chemosensitivity in myeloma KM3/DDP and U266/ADM cell lines.
Int. J. Clin. Exp. Pathol. 8:2300-2310(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_GZ72
Encyclopedic resources Wikidata; Q54973632
Entry history
Entry creation26-Sep-2016
Last entry update19-Dec-2024
Version number15