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Cellosaurus UCDK9B5 (CVCL_GY14)

[Text version]
Cell line name UCDK9B5
Accession CVCL_GY14
Resource Identification Initiative To cite this cell line use: UCDK9B5 (RRID:CVCL_GY14)
Comments Problematic cell line: Contaminated. Shown to be a Jurkat derivative (DOI=10.1016/j.leukres.2012.09.007, ICLAC). Originally thought to be of dog origin and to originate from a lymphoma from a male Greyhound.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00544.
Population: Caucasian.
Miscellaneous: Samples were supplied to ICLAC for STR profiling by Kent M. (UCSD) and tested by Hall E. (Genetica DNA Laboratories).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ICLAC

Markers:
AmelogeninX,Y
CSF1PO11,12,13
D3S135815,17
D5S8189
D7S8208,12
D8S117912,13,14
D13S3178,12
D16S53911
D18S5113,20,21
D21S1131.2,33.2
FGA20,21
Penta D11,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=22136758; DOI=10.1016/j.leukres.2011.11.004; PMCID=PMC5404115
Zwingenberger A.L., Vernau W., Shi C.-Y., Yan W.-S., Chen X.-B., Gordon I.K., Kent M.S.
Development and characterization of 5 canine B-cell lymphoma cell lines.
Leuk. Res. 36:601-606(2012)

DOI=10.1016/j.leukres.2012.09.007
Zwingenberger A.L., Vernau W., Shi C.-Y., Yan W.-S., Chen X.-B., Gordon I.K., Kent M.S.
Corrigendum to 'Development and characterization of 5 canine B-cell lymphoma cell lines' [Leuk. Res. 36(5) (2011) 601-606].
Leuk. Res. 37:120-120(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_GY14
Encyclopedic resources Wikidata; Q54989607
Entry history
Entry creation26-Sep-2016
Last entry update02-May-2024
Version number19