| Cell line name |
CH7C17 |
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| Synonyms |
CH7-C17 |
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| Accession |
CVCL_GX97 |
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| Resource Identification Initiative |
To cite this cell line use: CH7C17 (RRID:CVCL_GX97) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12155; TRB (Note=From HA1.7).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1316 (J.RT3-T3.5) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=1588277; DOI=10.1084/jem.175.6.1493; PMCID=PMC2119262
Hewitt C.R.A., Lamb J.R., Hayball J., Hill M., Owen M.J., O'Hehir R.E.
Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor.
J. Exp. Med. 175:1493-1499(1992) PubMed=7614994; DOI=10.1002/eji.1830250627
Wedderburn L.R., Searle S.J.M., Rees A.R., Lamb J.R., Owen M.J.
Mapping T cell recognition: the identification of a T cell receptor residue critical to the specific interaction with an influenza hemagglutinin peptide.
Eur. J. Immunol. 25:1654-1662(1995) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_GX97
TOKU-E; 4175
|
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| Encyclopedic resources |
Wikidata; Q54811640
|
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| Experimental variables resources |
EFO; EFO_0022518
|
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| Entry history |
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| Entry creation | 26-Sep-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 11 |
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