ID   V79-rCYP1A2
AC   CVCL_GR63
SY   V79MZr1A2; XEMd-MZ; XEMd.MZ; XEMdMZ
DR   Wikidata; Q54994669
RX   PubMed=1441600;
RX   PubMed=1793487;
RX   PubMed=1800893;
RX   PubMed=7565906;
RX   PubMed=8236270;
RX   PubMed=10474822;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=RGD; 2459; Cyp1a2.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_4V36 ! V79MZ
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 26-09-16; Last updated: 10-09-24; Version: 11
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RX   PubMed=1441600; DOI=10.3109/00498259209051863;
RA   Doehmer J., Wolfel C., Dogra S., Doehmer C., Seidel A., Platt K.-L.,
RA   Oesch F., Glatt H.-R.;
RT   "Applications of stable V79-derived cell lines expressing rat
RT   cytochromes P4501A1, 1A2, and 2B1.";
RL   Xenobiotica 22:1093-1099(1992).
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RX   PubMed=1793487; DOI=10.1002/mc.2940040613;
RA   Wolfel C., Platt K.-L., Dogra S., Glatt H.-R., Wachter F., Doehmer J.;
RT   "Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of
RT   17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster cells.";
RL   Mol. Carcinog. 4:489-498(1991).
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RX   PubMed=1800893; DOI=10.1093/mutage/6.6.461;
RA   Ellard S., Mohammed Y., Dogra S., Wolfel C., Doehmer J., Parry J.M.;
RT   "The use of genetically engineered V79 Chinese hamster cultures
RT   expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus
RT   assays.";
RL   Mutagenesis 6:461-470(1991).
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RX   PubMed=7565906; DOI=10.1016/0165-7992(95)00034-8;
RA   Simi S., Morelli S., Gervasi P.G., Rainaldi G.;
RT   "Clastogenicity of anthraquinones in V79 and in three derived cell
RT   lines expressing P450 enzymes.";
RL   Mutat. Res. 347:151-156(1995).
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RX   PubMed=8236270; DOI=10.1016/0300-483x(93)90063-x;
RA   Doehmer J.;
RT   "V79 Chinese hamster cells genetically engineered for cytochrome P450
RT   and their use in mutagenicity and metabolism studies.";
RL   Toxicology 82:105-118(1993).
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RX   PubMed=10474822; DOI=10.1093/mutage/14.1.57;
RA   Simi S., Xiao Y., Campagna M., Doehmer J., Darroudi F.;
RT   "Dual-colour FISH analysis to characterize a marker chromosome in
RT   cytochrome P450 2B1 recombinant V79 Chinese hamster cells.";
RL   Mutagenesis 14:57-61(1999).
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