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Cellosaurus V79-rCYP1A1 (CVCL_GR62)

[Text version]
Cell line name V79-rCYP1A1
Synonyms V79MZr1A1; V79-XEM2; XEM2
Accession CVCL_GR62
Resource Identification Initiative To cite this cell line use: V79-rCYP1A1 (RRID:CVCL_GR62)
Comments Karyotypic information: 22,X,-5,+5q (PubMed=10474822).
Genetic integration: Method=Transfection/transduction; Gene=RGD; 2458; Cyp1a1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_4V36 (V79MZ)
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=1692605
Dogra S., Doehmer J., Glatt H.-R., Molders H., Siegert P., Friedberg T., Seidel A., Oesch F.
Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
Mol. Pharmacol. 37:608-613(1990)

PubMed=1800893; DOI=10.1093/mutage/6.6.461
Ellard S., Mohammed Y., Dogra S., Wolfel C., Doehmer J., Parry J.M.
The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.
Mutagenesis 6:461-470(1991)

PubMed=1441600; DOI=10.3109/00498259209051863
Doehmer J., Wolfel C., Dogra S., Doehmer C., Seidel A., Platt K.-L., Oesch F., Glatt H.-R.
Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1.
Xenobiotica 22:1093-1099(1992)

PubMed=8236270; DOI=10.1016/0300-483x(93)90063-x
Doehmer J.
V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies.
Toxicology 82:105-118(1993)

PubMed=7565906; DOI=10.1016/0165-7992(95)00034-8
Simi S., Morelli S., Gervasi P.G., Rainaldi G.
Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes.
Mutat. Res. 347:151-156(1995)

PubMed=10474822; DOI=10.1093/mutage/14.1.57
Simi S., Xiao Y., Campagna M., Doehmer J., Darroudi F.
Dual-colour FISH analysis to characterize a marker chromosome in cytochrome P450 2B1 recombinant V79 Chinese hamster cells.
Mutagenesis 14:57-61(1999)

Cross-references
Encyclopedic resources Wikidata; Q54994668
Entry history
Entry creation26-Sep-2016
Last entry update10-Sep-2024
Version number11