ID   V79-rCYP2B1
AC   CVCL_GR60
SY   V79MZr2B1; V79/SD1; SD1; SD-1
DR   TOKU-E; 4043
DR   Wikidata; Q54992618
RX   PubMed=1441600;
RX   PubMed=1800893;
RX   PubMed=3137560;
RX   PubMed=7565906;
RX   PubMed=8596476;
RX   PubMed=10474822;
CC   Karyotypic information: 21,X,-7,-8der,+mar (PubMed=10474822).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=RGD; 2466; Cyp2b1.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_4V36 ! V79MZ
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 26-09-16; Last updated: 10-09-24; Version: 11
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RX   PubMed=1441600; DOI=10.3109/00498259209051863;
RA   Doehmer J., Wolfel C., Dogra S., Doehmer C., Seidel A., Platt K.-L.,
RA   Oesch F., Glatt H.-R.;
RT   "Applications of stable V79-derived cell lines expressing rat
RT   cytochromes P4501A1, 1A2, and 2B1.";
RL   Xenobiotica 22:1093-1099(1992).
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RX   PubMed=1800893; DOI=10.1093/mutage/6.6.461;
RA   Ellard S., Mohammed Y., Dogra S., Wolfel C., Doehmer J., Parry J.M.;
RT   "The use of genetically engineered V79 Chinese hamster cultures
RT   expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus
RT   assays.";
RL   Mutagenesis 6:461-470(1991).
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RX   PubMed=3137560; DOI=10.1073/pnas.85.16.5769; PMCID=PMC281846;
RA   Doehmer J., Dogra S., Friedberg T., Monier S., Adesnik M., Glatt H.-R.,
RA   Oesch F.;
RT   "Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster
RT   cells (V79) and metabolic activation of aflatoxin B1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:5769-5773(1988).
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RX   PubMed=7565906; DOI=10.1016/0165-7992(95)00034-8;
RA   Simi S., Morelli S., Gervasi P.G., Rainaldi G.;
RT   "Clastogenicity of anthraquinones in V79 and in three derived cell
RT   lines expressing P450 enzymes.";
RL   Mutat. Res. 347:151-156(1995).
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RX   PubMed=8596476; DOI=10.1093/mutage/10.6.549;
RA   Ellard S., James S.A., Parry E.M., Parry J.M.;
RT   "A genetically engineered V79 cell line SD1 expressing rat CYP2B1
RT   exhibits chromosomal instability at the integration site of the
RT   transfected DNA.";
RL   Mutagenesis 10:549-554(1995).
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RX   PubMed=10474822; DOI=10.1093/mutage/14.1.57;
RA   Simi S., Xiao Y., Campagna M., Doehmer J., Darroudi F.;
RT   "Dual-colour FISH analysis to characterize a marker chromosome in
RT   cytochrome P450 2B1 recombinant V79 Chinese hamster cells.";
RL   Mutagenesis 14:57-61(1999).
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