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Cellosaurus 4T1.2 (CVCL_GR32)

[Text version]
Cell line name 4T1.2
Accession CVCL_GR32
Resource Identification Initiative To cite this cell line use: 4T1.2 (RRID:CVCL_GR32)
Comments Characteristics: High propensity to metastasize spontaneously to bone, causing fractures and/or hindlimb paralysis (ATCC=CRL-3406).
Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cfC3H.
Hierarchy Parent: CVCL_0125 (4T1)
Children:
CVCL_E3GI (HyCyte 4T1.2-Luc)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=10411109; DOI=10.1023/A:1006689719505
Lelekakis M., Moseley J.M., Martin T.J., Hards D., Williams E.D., Ho P.W.M., Lowen D., Javni J., Miller F.R., Slavin J., Anderson R.L.
A novel orthotopic model of breast cancer metastasis to bone.
Clin. Exp. Metastasis 17:163-170(1999)

PubMed=15671244; DOI=10.1158/1541-7786.1.3.1
Eckhardt B.L., Parker B.S., van Laar R.K., Restall C.M., Natoli A.L., Tavaria M.D., Stanley K.L., Sloan E.K., Moseley J.M., Anderson R.L.
Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix.
Mol. Cancer Res. 3:1-13(2005)

Cross-references
Cell line collections (Providers) ATCC; CRL-3406
Chemistry resources ChEMBL-Cells; CHEMBL4483001
ChEMBL-Targets; CHEMBL4483221
PubChem_Cell_line; CVCL_GR32
Encyclopedic resources Wikidata; Q54603658
Entry history
Entry creation26-Sep-2016
Last entry update19-Dec-2024
Version number8