Cellosaurus cell line 4T1.2 (CVCL

Cellosaurus 4T1.2 (CVCL_GR32)

Cross-references
Cell line name	4T1.2
Accession	CVCL_GR32
Resource Identification Initiative	To cite this cell line use: 4T1.2 (RRID:CVCL_GR32)
Comments	Characteristics: High propensity to metastasize spontaneously to bone, causing fractures and/or hindlimb paralysis (ATCC=CRL-3406). Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG). Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease	Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: BALB/cfC3H.
Hierarchy	Parent: CVCL_0125 (4T1)
Sex of cell	Female
Category	Cancer cell line
Publications	PubMed=10411109; DOI=10.1023/A:1006689719505 Lelekakis M., Moseley J.M., Martin T.J., Hards D., Williams E.D., Ho P., Lowen D., Javni J., Miller F.R., Slavin J., Anderson R.L. A novel orthotopic model of breast cancer metastasis to bone. Clin. Exp. Metastasis 17:163-170(1999) PubMed=15671244; DOI=10.1158/1541-7786.1.3.1 Eckhardt B.L., Parker B.S., van Laar R.K., Restall C.M., Natoli A.L., Tavaria M.D., Stanley K.L., Sloan E.K., Moseley J.M., Anderson R.L. Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Mol. Cancer Res. 3:1-13(2005)
Cell line collections (Providers)	ATCC; CRL-3406
Chemistry resources	ChEMBL-Cells; CHEMBL4483001 ChEMBL-Targets; CHEMBL4483221 PubChem_Cell_line; CVCL_GR32
Encyclopedic resources	Wikidata; Q54603658
Entry history
Entry creation	26-Sep-2016
Last entry update	29-Jun-2023
Version number	7