ID   YUDOSO
AC   CVCL_G323
DR   cancercelllines; CVCL_G323
DR   Cosmic; 1548852
DR   Cosmic; 2439312
DR   Wikidata; Q54995650
RX   PubMed=20149136;
RX   PubMed=21521745;
RX   PubMed=21543894;
RX   PubMed=21569352;
RX   PubMed=23012583;
RX   PubMed=26214590;
CC   Part of: Yale University (YU) melanoma cell collection.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=26214590).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=20149136; PubMed=26214590).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   84Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 17
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RX   PubMed=20149136; DOI=10.1111/j.1755-148X.2010.00685.x; PMCID=PMC2848976;
RA   Halaban R., Zhang W., Bacchiocchi A., Cheng E., Parisi F., Ariyan S.,
RA   Krauthammer M., McCusker J.P., Kluger Y., Sznol M.;
RT   "PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK
RT   pathway and enhances cell migration and proliferation of BRAF melanoma
RT   cells.";
RL   Pigment Cell Melanoma Res. 23:190-200(2010).
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RX   PubMed=21521745; DOI=10.1158/1541-7786.MCR-10-0512; PMCID=PMC3117976;
RA   Tworkoski K., Singhal G., Szpakowski S., Zito C.I., Bacchiocchi A.,
RA   Muthusamy V., Bosenberg M.W., Krauthammer M., Halaban R., Stern D.F.;
RT   "Phosphoproteomic screen identifies potential therapeutic targets in
RT   melanoma.";
RL   Mol. Cancer Res. 9:801-812(2011).
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RX   PubMed=21543894; DOI=10.4161/cc.10.11.15777; PMCID=PMC3233487;
RA   Chan E., Patel R., Nallur S., Ratner E., Bacchiocchi A., Hoyt K.,
RA   Szpakowski S., Godshalk S., Ariyan S., Sznol M., Halaban R.,
RA   Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.;
RT   "MicroRNA signatures differentiate melanoma subtypes.";
RL   Cell Cycle 10:1845-1852(2011).
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RX   PubMed=21569352; DOI=10.1186/1471-2164-12-230; PMCID=PMC3114747;
RA   Parisi F., Ariyan S., Narayan D., Bacchiocchi A., Hoyt K., Cheng E.,
RA   Xu F., Li P.-N., Halaban R., Kluger Y.;
RT   "Detecting copy number status and uncovering subclonal markers in
RT   heterogeneous tumor biopsies.";
RL   BMC Genomics 12:230.1-230.14(2011).
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RX   PubMed=23012583; PMCID=PMC3447199;
RA   Parisi F., Micsinai M., Strino F., Ariyan S., Narayan D.,
RA   Bacchiocchi A., Cheng E., Xu F., Li P.-N., Kluger H.M., Halaban R.,
RA   Kluger Y.;
RT   "Integrated analysis of tumor samples sheds light on tumor
RT   heterogeneity.";
RL   Yale J. Biol. Med. 85:347-361(2012).
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RX   PubMed=26214590; DOI=10.1038/ng.3361; PMCID=PMC4916843;
RA   Krauthammer M., Kong Y., Bacchiocchi A., Evans P., Pornputtapong N.,
RA   Wu C., McCusker J.P., Ma S.-G., Cheng E., Straub R., Serin M.,
RA   Bosenberg M.W., Ariyan S., Narayan D., Sznol M., Kluger H.M., Mane S.M.,
RA   Schlessinger J., Lifton R.P., Halaban R.;
RT   "Exome sequencing identifies recurrent mutations in NF1 and RASopathy
RT   genes in sun-exposed melanomas.";
RL   Nat. Genet. 47:996-1002(2015).
//