ID   WW165
AC   CVCL_G321
DR   cancercelllines; CVCL_G321
DR   Cosmic; 1197385
DR   Cosmic; 1548845
DR   Wikidata; Q54994575
RX   PubMed=20149136;
RX   PubMed=21521745;
RX   PubMed=26214590;
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (PubMed=20149136; PubMed=26214590).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   62Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 13
//
RX   PubMed=20149136; DOI=10.1111/j.1755-148X.2010.00685.x; PMCID=PMC2848976;
RA   Halaban R., Zhang W., Bacchiocchi A., Cheng E., Parisi F., Ariyan S.,
RA   Krauthammer M., McCusker J.P., Kluger Y., Sznol M.;
RT   "PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK
RT   pathway and enhances cell migration and proliferation of BRAF melanoma
RT   cells.";
RL   Pigment Cell Melanoma Res. 23:190-200(2010).
//
RX   PubMed=21521745; DOI=10.1158/1541-7786.MCR-10-0512; PMCID=PMC3117976;
RA   Tworkoski K., Singhal G., Szpakowski S., Zito C.I., Bacchiocchi A.,
RA   Muthusamy V., Bosenberg M.W., Krauthammer M., Halaban R., Stern D.F.;
RT   "Phosphoproteomic screen identifies potential therapeutic targets in
RT   melanoma.";
RL   Mol. Cancer Res. 9:801-812(2011).
//
RX   PubMed=26214590; DOI=10.1038/ng.3361; PMCID=PMC4916843;
RA   Krauthammer M., Kong Y., Bacchiocchi A., Evans P., Pornputtapong N.,
RA   Wu C., McCusker J.P., Ma S.-G., Cheng E., Straub R., Serin M.,
RA   Bosenberg M.W., Ariyan S., Narayan D., Sznol M., Kluger H.M., Mane S.M.,
RA   Schlessinger J., Lifton R.P., Halaban R.;
RT   "Exome sequencing identifies recurrent mutations in NF1 and RASopathy
RT   genes in sun-exposed melanomas.";
RL   Nat. Genet. 47:996-1002(2015).
//