ID   PNP-Mel
AC   CVCL_G320
SY   PNP Mel
DR   cancercelllines; CVCL_G320
DR   Cosmic; 1295330
DR   Wikidata; Q54947677
RX   PubMed=11121133;
RX   PubMed=19799798;
RX   PubMed=21424129;
RX   PubMed=29492214;
CC   From: Guadagni, Fiorella; Regina Elena Institute for Cancer Research; Rome; Italy.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=19799798; PubMed=29492214).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Gly101Trp (c.301G>T) (p.Arg115Leu, c.344G>T); ClinVar=VCV000009412; Zygosity=Unspecified (PubMed=19799798; PubMed=29492214).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_M744 ! PNM-Mel
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 15
//
RX   PubMed=11121133; DOI=10.1046/j.1523-1747.2000.00199.x;
RA   Lacal P.M., Failla C.M., Pagani E., Odorisio T., Schietroma C.,
RA   Falcinelli S., Zambruno G., D'Atri S.;
RT   "Human melanoma cells secrete and respond to placenta growth factor
RT   and vascular endothelial growth factor.";
RL   J. Invest. Dermatol. 115:1000-1007(2000).
//
RX   PubMed=19799798; DOI=10.1186/1471-2407-9-352; PMCID=PMC2763007;
RA   Casula M., Muggiano A., Cossu A., Budroni M., Caraco C.,
RA   Ascierto P.A., Pagani E., Stanganelli I., Canzanella S., Sini M.C.,
RA   Palomba G., Palmieri G.;
RG   Italian Melanoma Intergroup (IMI);
RT   "Role of key-regulator genes in melanoma susceptibility and
RT   pathogenesis among patients from South Italy.";
RL   BMC Cancer 9:352.1-352.11(2009).
//
RX   PubMed=21424129; DOI=10.3892/or.2011.1220;
RA   Manca A., Sini M.C., Izzo F., Ascierto P.A., Tatangelo F., Botti G.,
RA   Gentilcore G., Capone M., Mozzillo N., Rozzo C., Cossu A., Tanda F.,
RA   Palmieri G.;
RT   "Induction of arginosuccinate synthetase (ASS) expression affects the
RT   antiproliferative activity of arginine deiminase (ADI) in melanoma
RT   cells.";
RL   Oncol. Rep. 25:1495-1502(2011).
//
RX   PubMed=29492214; DOI=10.18632/oncotarget.23989; PMCID=PMC5823576;
RA   Sini M.C., Doneddu V., Paliogiannis P., Casula M., Colombino M.,
RA   Manca A., Botti G., Ascierto P.A., Lissia A., Cossu A., Palmieri G.;
RT   "Genetic alterations in main candidate genes during melanoma
RT   progression.";
RL   Oncotarget 9:8531-8541(2018).
//