ID   SCCIC8
AC   CVCL_G302
SY   IC8
DR   CancerTools; 153668
DR   Cosmic; 1608873
DR   Cosmic; 2688669
DR   GEO; GSM2611464
DR   GEO; GSM2611465
DR   GEO; GSM2611466
DR   Wikidata; Q54952382
DR   Ximbio; 153668
RX   PubMed=22006338;
RX   PubMed=24662767;
RX   PubMed=31336867;
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Gln1687Ter (c.5059C>T); Zygosity=Unspecified (PubMed=22006338; PubMed=24662767).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Buttock, skin; UBERON=UBERON_8480014.
ST   Source(s): PubMed=31336867
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 13,18
ST   D19S433: 13.1,14
ST   D21S11: 29
ST   D2S1338: 17,21
ST   D3S1358: 16
ST   D5S818: 13
ST   D7S820: 8,12
ST   D8S1179: 16
ST   FGA: 19,23
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 15,16
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 12
//
RX   PubMed=22006338; DOI=10.1073/pnas.1114669108; PMCID=PMC3203814;
RA   Wang N.J., Sanborn Z., Arnett K.L., Bayston L.J., Liao W., Proby C.M.,
RA   Leigh I.M., Collisson E.A., Gordon P.B., Jakkula L.R., Pennypacker S.,
RA   Zou Y., Sharma M., North J.P., Vemula S.S., Mauro T.M., Neuhaus I.M.,
RA   LeBoit P.E., Hur J.S., Park K., Huh N., Kwok P.-Y., Arron S.T.,
RA   Massion P.P., Bale A.E., Haussler D., Cleaver J.E., Gray J.W.,
RA   Spellman P.T., South A.P., Aster J.C., Blacklow S.C., Cho R.J.;
RT   "Loss-of-function mutations in Notch receptors in cutaneous and lung
RT   squamous cell carcinoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:17761-17766(2011).
//
RX   PubMed=24662767; DOI=10.1038/jid.2014.154; PMCID=PMC4753672;
RA   South A.P., Purdie K.J., Watt S.A., Haldenby S., den Breems N.Y.,
RA   Dimon M., Arron S.T., Kluk M.J., Aster J.C., McHugh A., Xue D.J.,
RA   Dayal J.H.S., Robinson K.S., Rizvi S.M.H., Proby C.M., Harwood C.A.,
RA   Leigh I.M.;
RT   "NOTCH1 mutations occur early during cutaneous squamous cell
RT   carcinogenesis.";
RL   J. Invest. Dermatol. 134:2630-2638(2014).
//
RX   PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499;
RA   Hassan S., Purdie K.J., Wang J., Harwood C.A., Proby C.M.,
RA   Pourreyron C., Mladkova N., Nagano A., Dhayade S., Athineos D.,
RA   Caley M., Mannella V., Blyth K., Inman G.J., Leigh I.M.;
RT   "A Unique panel of patient-derived cutaneous squamous cell carcinoma
RT   cell lines provides a preclinical pathway for therapeutic testing.";
RL   Int. J. Mol. Sci. 20:3428.1-3428.26(2019).
//