ID   CFT1
AC   CVCL_G214
DR   Kerafast; ENC001
DR   Wikidata; Q54811462
RX   DOI=10.1007/978-1-4612-0411-4_17;
RX   Patent=US5576206;
RX   PubMed=7684560;
RX   PubMed=15463957;
CC   Group: Patented cell line.
CC   Doubling time: 36.3 hours (Note=At 14th passage) (PubMed=7684560).
CC   Sequence variation: Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18) [Note=pUC19].
CC   Derived from site: In situ; Trachea; UBERON=UBERON_0003126.
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   24Y
CA   Transformed cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 16
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RX   DOI=10.1007/978-1-4612-0411-4_17;
RA   Conrad M., Yankaskas J.R., Boucher R.C., Schlegel R.;
RT   "Using the papillomavirus E6/E7 genes to generate well-differentiated
RT   epithelial cell lines.";
RL   (In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.163-167; Humana Press; New York (1990).
//
RX   Patent=US5576206;
RA   Schlegel R.;
RT   "Human papilloma virus genes and their use in gene therapy.";
RL   Patent number US5576206, 19-Nov-1996.
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RX   PubMed=7684560; DOI=10.1152/ajpcell.1993.264.5.C1219;
RA   Yankaskas J.R., Haizlip J.E., Conrad M., Koval D., Lazarowski E.,
RA   Paradiso A.M., Rinehart C.A. Jr., Sarkadi B., Schlegel R.,
RA   Boucher R.C.;
RT   "Papilloma virus immortalized tracheal epithelial cells retain a
RT   well-differentiated phenotype.";
RL   Am. J. Physiol. 264:C1219-C1230(1993).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//